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IRF Datasheet, PDF – Datasheet Search Engine
Structure of a chromosomal gene for human interferon beta. In this study, we describe a nuclear factor, termed interferon regulatory factor-1 IRF-1that is involved in the transcription of IFN-beta and possibly other genes.
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National Center for Biotechnology InformationU. A nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus. Sequencing end-labeled DNA with base-specific chemical cleavages. Interaction of positive and negative regulatory proteins in the galactose regulon of yeast.
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Reversible silencing of enhancers irrf sequences derived from the human IFN-alpha promoter. Regulation of cytokine gene expression. Regulation of gene expression by interferons: Establishment of a permanent cell line HEL-R66 from human embryonic lung cells with high susceptibility to viruses.
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Biochemistry of interferons and their actions. IRF-1 may also be involved in silencing the function of the SV40 enhancer juxtaposed to the regulatory orf in uninduced cells.
Short and long range activation by the SV40 enhancer. Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.
A rapid and sensitive assay system for bacterial gpt activity in transfected mammalian cells. Intracytoplasmic phosphorylation sites of Tac antigen p55 are not essential for the conformation, function, and regulation of the human if 2 receptor. Support Center Support Center.
Associated Data Supplementary Materials. Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. The human beta-interferon gene enhancer is under negative control. Controlled transcription of a human alpha-interferon gene introduced into mouse L cells.
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Human embryonic lung cells HEL-R66 are of monkey origin. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Our data suggest that IRF-1 participates in the transient formation of an induction-specific irrf es with the regulatory elements.
BK viral enhancer element and a human cellular homolog.
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Affinity purification of sequence-specific DNA binding proteins. Human beta-interferon gene lrf is regulated by an inducible enhancer element. Heat shock factor is regulated differently in yeast and HeLa cells.
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Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis. Abstract Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some 46110.
The 5′-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. Transcription of the human interferon-beta Irc gene is induced by a variety of agents such as viruses, dsRNA and some cytokines.
High efficiency DNA-mediated transformation of primate cells.