ANGIOFIBROMA NASOFARINGEO PDF

Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

Author: Goltishicage Doubei
Country: Central African Republic
Language: English (Spanish)
Genre: Spiritual
Published (Last): 24 March 2007
Pages: 86
PDF File Size: 13.91 Mb
ePub File Size: 9.96 Mb
ISBN: 329-1-36033-784-5
Downloads: 66557
Price: Free* [*Free Regsitration Required]
Uploader: Fenrigami

Juvenile nasopharyngeal angiofibroma

Thus, early diagnosis, accurate staging and adequate treatment are essential in the management of this lesion. However, as in any invasive procedure, embolization presents risks that should be fully explained to the patients Mesothelioma Malignant solitary fibrous tumor.

Antral sign or Holman-Miller sign forward bowing of posterior wall of maxilla is pathognomic of angiofibroma. These classifications are very important in helping surgeons decide the appropriate surgical approach. The encounter of two copies of AR gene in JNA cells cores, along with the presence of AR, remarks the importance of androgen stimulation in this tumor pathogenesis. The tumor invades the infratemporal fossa or orbit without intracranial involvement.

The combination of different accesses to the tumor can be required 9.

Endoscopic Ressection of Juvenile Angiofibroma: Angiofibromaa control of bleeding during the resection of nasopharyngeal angiofibromas can be achieved successfully by temporary clamping of the external carotid arteries in the neck Genetic nasofaringgeo in juvenile nasopharyngeal angiofibromas. The histologic origin of JNA involves vascular endothelial cells or fibroblasts.

TOP Related Posts  KALABRIEN REISEFHRER PDF

Exclusively endoscopic removal of juvenile nasopharyngeal angiofibroma: Recent angioibroma and genetic studies throw some light on this topic.

The JNA is a highly vascularized tumor and its probable original site is in the upper margin of the sphenopalatine foramen 1,3. A comparative study of surgical approches. Many studies highlight the benefit of preoperative arterial embolization to control bleeding intraoperative 16,29, Arch Pathol Lab Med ; Long-term tumor recurrence has been reported due to incomplete initial resection.

Pathology Outlines – Nasopharyngeal angiofibroma

Impaired Eustachian tube function, facial deformity, proptosis and changes in visual acuity may be seen. Juvenile nasopharyngeal angiofibroma NAJ is a tumor with vascular component, slow growing, benign but very aggressive because of its local invasiveness.

Improvements in surgical techniques are designed to shorten surgical time and thereby reduce patient morbidity.

The color depends on the vascular component and may vary from pale white in less vascular lesions to a pink and wine colored mass in highly vascularized ones.

JNA is benign but locally destructive.

Nasopharyngeal angiofibroma

Open in a separate window. Article accepted in April 21, We performed a columellar incision intersects similar to access to the perichondrium of the septum septoplasty nasoangiofibroma the opposite side. Sanchez de Guzman G. Find articles by Francis Vinicius Fontes de Lima.

Molecular factors Too little is known about the growth factors involved in the JNA pathogenesis, and its initiation and progression mechanisms are not very well known. The most significant risk is blindness, angipfibroma patients with occlusion of the ophthalmic or middle cerebral artery through the collateral circulation. Avid enhancement is noted on contrast-enhanced CT. Otolaryngol Head Neck Surg.

TOP Related Posts  BARRANCA ABAJO FLORENCIO SANCHEZ PDF

Endoscopic Surgery of Nasopharyngeal Angiofibroma

The most solid basic knowledge regarding the JNA is pursuant to its histology. The most significant risk is blindness, for patients with occlusion of the ophthalmic or middle cerebral artery through the collateral circulation. Arterial embolization in the management of posterior epistaxis.

To remove the tumor in two angiofinroma, the tumor section was performed in two halves, the largest of which was removed by transoral route.

Since an abnormality in the hypothalamic axis was proposed by Schif 38as a JNA pathogenesis theory, the expression of hormonal receptors in the JNA has already been the nasogaringeo of many studies. In spite of the existing controversy, the hormonal stimulation means remains a JNA therapeutic possible target. Nasopharyngeal angiofibroma also called juvenile nasopharyngeal angiofibroma [1] [2] is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity.

Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

Author: Douzahn Zologar
Country: Sweden
Language: English (Spanish)
Genre: Health and Food
Published (Last): 8 February 2009
Pages: 45
PDF File Size: 8.83 Mb
ePub File Size: 19.49 Mb
ISBN: 921-5-25097-922-1
Downloads: 76019
Price: Free* [*Free Regsitration Required]
Uploader: Bajinn

The IGFII gene undergoes maternal imprinting, that is, expresses normally only the paternal allele Find articles by Francis Vinicius Fontes de Lima. The JNA histology has been closely related to the symptoms duration in the disease presentation. Angiofibromq also found that patients who underwent clamping of nasofarungeo external carotid artery and embolization showed less intraoperative bleeding than patients who underwent embolization alone.

Exclusively endoscopic removal of juvenile nasopharyngeal angiofibroma: Reviewing JNA’s pathogenesis, emphasizing genetic and molecular anigofibroma. More recently, the tumor definition as dependent on androgenic has been questioned 43which can help explain the unconcluded results and the unpredictability of treatment with anti-androgenic 44, The main clinical presentation of JNA is unilateral nasal obstruction with or without epistaxis.

Intraoperative control of bleeding during the resection of nasopharyngeal angiofibromas can be achieved successfully by temporary clamping of the external carotid arteries in the neck Transcatheter arterial embolization in nasopharyngeal angiofibroma.

Any lesion with this presentation may be confused with JNA. It impinges on adjacent structures and causes pressure erosion of bone. Discussion Juvenile nasopharyngeal angiofibromas present almost exclusively in men aged years This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

Blood loss, which was mL in a non-embolized patient, was reduced to mL in embolized patients Occurs angofibroma entirely pre-adolescent and adolescent males, perhaps to respond to androgens 2,3,4,5,9.

Nasopharyngeal Angiofibroma: Review of the Genetic and Molecular Aspects

In spite of the scarce data describing the JNA etiology and pathogenesis, genetic and molecular factors seem to collaborate to the understanding of the disease’s many clinical and morphological features. Despite the advances in the field of anatomopathologic description, there are a few studies concerning the JNA molecular and genetic aspects.

TOP Related Posts  BUKU PEREKONOMIAN INDONESIA TULUS TAMBUNAN PDF

Click here for information on linking to our website or using our content or images. Ear Nose Throat J. Arteriography followed by preoperative embolization and surgical resection is the treatment of choice.

Typically a lobulated non-encapsulated soft tissue mass is demonstrated centred on the sphenopalatine foramen which is often widened and usually bowing the posterior wall of the maxillary antrum anteriorly. Patients may present with life-threatening epistaxis. Arch Otolaryngol Head Neck Surg. The mean operation time was min, and the mean bleeding volume was mL. Please review our privacy policy.

Our patients were classified using the Fisch system, the most widely used in most studies Figures 2 and 3. However, no changes are found in the sexual hormones serum levels 39,42 nor changes in the JNA patients sexual maturity.

It accounts for 0. They may be locally aggressive. Molecular factors Too little is known about the growth factors involved in the JNA pathogenesis, and its initiation and progression mechanisms are not very well known. Surgical approaches for conventional techniques include transpalatal, transmaxillary, lateral rhinotomy, mid-facial degloving, extended sublabial Denker, and Le Fort type I osteotomy 11 13 20 CT of a year-old patient with a Fisch class II juvenile nasopharyngeal angiofibroma.

Kaklamani VG, Pasche B.

Nasopharyngeal angiofibroma

Expression of growth factors, protooncogenes and p53 in nasopharyngeal angiofibromas. HUANG et al 25 show that the technique with two surgeons via the transseptal later shows less morbidity and lower rate of recurrence after resection of the tumor proper.

To remove the tumor in two patients, the tumor section was performed in two halves, the largest of which was removed by transoral route. These tests have led to the formulations of multiple classification methods, including the FischR adkowskiA ndrewsB remerand A ntonelli methods 1 4 5 7 8. We can see that this technique allows easier resection of large tumors staged as SCI.

After this sequence was performed inferior turbinectomy nearest the insertion of the inferior turbinate to the lateral nasal wall, with subsequent removal of the medial wall of maxilla.

TOP Related Posts  LIBRO DE CALCULO CON GEOMETRIA ANALITICA DE SWOKOWSKI EN PDF

Angiofibroma nasofaríngeo juvenil

So there is need for further action to claim that this technique has a low recurrence rate, since the recurrence is probably related to incomplete resection the initial tumor.

Ras mutations and expression in head and neck squamous cell carcinomas. Specifically, genes of Rab via and proteins of connection to the retinoblastoma, among others, were found in several amplified regions and both of them have their overexpression associated to other tumors.

This relatively low blood loss may be due to the use of surgical endoscopy, providing better control of bleeding than open surgery, with or without endoscopy. The first patient who underwent ajgiofibroma in our department had a Fisch I tumor, but did not undergo embolization or clamping of the external carotid arteries.

Extraoral examination revealed normal appearing overlying skin. Surgical methods in all patients were based on Fisch classifications. In another large series, twenty four cases out or twenty seven had a VEGF significant marking, while the TGF-beta marking was found in fourteen cases and both could exercise a role in the tumor pathogenesis by the promotion of angiogenesis and cellular angiogenesis For after septoplasty, a window was made in the cartilaginous septum, enabling you to enter through this passage one or two tools in handling the second surgeon.

Nasopharyngeal angiofibroma: Our experience and literature review

The tumor histology and microstructure have been more recently clarified see general aspects of microscopy in Picture 2. Impaired Eustachian tube function, facial deformity, proptosis and changes in visual acuity may be seen. Angiofigroma of our patients experienced complications due to embolization. Although nasal endoscopic surgery is safe, rapid, and effective, studies are needed to assess the importance of preoperative embolization and clamping of the external carotid artery in reducing intraoperative bleeding.